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19 Once a patient has progressed to severe disease, high-dose corticosteroids, external beam radiation and steroid-sparing immunosuppressive agents for reducing the inflammation may be necessary

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Therefore, various mechanisms for the hypopigmentary effect of Glutathione and Vitamin C have been proposed, with inhibition of tyrosinase being the most important

doi: 10.1080/10401230701653377 265 BortolasciCCVargasHOSouza-NogueiraABarbosaDSMoreiraEGNunesSOet al

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